1. Novel Chemical Kinetics for Description of Chemical Noise in Small Heterogeneous Reaction Systems
The aim of this research is to understand the mechanism of biological control in biological networks, such as gene expression reaction network, of a single cell. We recently develop a novel chemical kinetics for efficient description of chemical noise in general biopolymer reactions. Application of the latter theory for quantification of gene expression noise is underway in collaboration with experimental group in this fields.
Lim, Kim, Park, Yang, Song, Chang, Lee and Sung, Phys. Rev. X (2015)
Lim, Park, Park, Cao, Silbey, Sung, J. Chem. Theor. Comp. (2012)
Yang, Cao, Silbey, Sung, Biophys. J. 101, 510 (2011)
Jung, Yang, Sung, J. Phys. Chem. B 114, 9840 (2010)
2. Nonequilibrium Work Fluctuation Theorem
For more than a decade, Jarzynski’s theory has been recognized as a universal statistical mechanical equation that provides the equilibrium free energy difference between two thermodynamic states in terms of the statistical distribution of work done during an arbitrary irreversible process connecting the two thermodynamic states. Recently, we first showed that the celebrated Jarzynski’s equality is not universal, and established the validity range of the equation proposed for estimation of free energy change during an arbitrary irreversible process. Currently, we are interested in developing the nonequilibrium work fluctuation theorem with a greater application range than Jarzynski’s equation.
3. Application of Statistical Mechanics to Nano Systems
Applications of the statistical thermodynamics to predict the signal of nano-sensory system and the adsorption isotherm of nanostructures are underway in our research group.
4. Statistical Mechanics of Small Systems
We generalize the Gibbs-Boltzmann statistical mechanics for an ensemble of small or mesoscopic solute molecules interacting with their environment. This fundamental research is pursued to achieve an accurate quantitative description of the solvation effects in chemical equilibrium, which are crucial in many fields of modern science. One of the goals of this research is to develop an efficient computational tool for prediction of equilibrium constant in solution phase.